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Contributor Information

  • Name Julian Gannon
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-Cdc20 [BA8]
  • Alternate names: APC/C activator protein CDC2; Cell division control protein 2; YGL116W; Cell Division Cycle 2; P55CDC; CDC2 Cell Division Cycle 2; BA276H19.3; CDC2A
  • Clone: BA8
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Xenopus laevis
  • Host: Mouse
  • Application: ELISA ; FACS ; WB
  • Strain: Balb/c
  • Description: Fizzy protein (cdc20) is associated with the activation of the anaphase-promoting complex (APC) at the onset of anaphase.
  • Immunogen: Peptide from the carboxy terminus of the protein.
  • Isotype: IgG2a
  • Research area: Cell Cycle ; Protein Degradation
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Cell division cycle protein 20 (cdc20)
  • Target background: Fizzy protein (cdc20) is associated with the activation of the anaphase-promoting complex (APC) at the onset of anaphase.

Application Details

  • Application: ELISA ; FACS ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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  • Available on request

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References

  • •  Ohe et al. 2010. Mol Biol Cell. 21(6):905-13. PMID: 20089832.
  • •  Emi2 inhibition of the anaphase-promoting complex/cyclosome absolutely requires Emi2 binding via the C-terminal RL tail.
  • •  Sironi et al. 2001. EMBO J. 20(22):6371-82. PMID: 11707408.
  • •  Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.
  • •  Lorca et al. 1998. EMBO J. 17(13):3565-75. PMID: 9649427.
  • •  Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts.