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Contributor Information

  • Name Edward Kipreos
  • Institute University of Georgia

Tool Details

  • Tool name: Anti-CYE1 [17C8]
  • Alternate names: CYE-1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Host: Mouse
  • Application: WB ; IF
  • Description: Cyclin E is a member of the cyclin family of proteins, which regulates the cell cycle through its activation of cyclin-dependent kinases. Specifically, cyclin E binds and activates the S phase Cdk2. The cyclin E–Cdk2 complex promotes the G1 to S phase cell cycle transition. Overexpression of cyclin E has been implicated in carcinomas among the gastrointestinal tract, including colon or stomach cancer as well as a marker for breast cancers
  • Immunogen: Full-length recombinant CYE-1 protein
  • Research area: Cell biology

  • For Research Use Only

Target Details

  • Target: Cyclin E
  • Target background: Cyclin E is a member of the cyclin family of proteins, which regulates the cell cycle through its activation of cyclin-dependent kinases. Specifically, cyclin E binds and activates the S phase Cdk2. The cyclin ECdk2 complex promotes the G1 to S phase cell cycle transition. Overexpression of cyclin E has been implicated in carcinomas among the gastrointestinal tract, including colon or stomach cancer as well as a marker for breast cancers

Application Details

  • Application: WB ; IF

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Kim et al. 2007. Mol Cell Biol. 27(4):1394-406. PMID: 17145765.
  • •  The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex.