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Contributor Information

  • Name Diane Wilcock
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-HSVUL42 [2H4]
  • Clone: 2H4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Virus
  • Host: Mouse
  • Application: IF ; WB ; ICC ; ELISA ; IHC ; IF ; IP ; WB
  • Strain: Balb/c
  • Description: 2H4 may be used to detect UL42 bound to HSV polymerase. Recognises amino acids 360-366 in UL42.
  • Immunogen: Baculovirus-expressed HSV DNA polymerase (POL) and POL/UL42 complex.
  • Isotype: IgG1
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Herpes Simplex Virus protein UL42 (HSV-UL42)
  • Target background: UL42 is the DNA polymerase accessory protein of herpes simplex virus type 1.

Application Details

  • Application: IF ; WB ; ICC ; ELISA ; IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

  • Available on request

References

  •   Lv et al. 2018. Antiviral Res. 159:55-62. PMID: 30266338.
  •   Dhner et al. 2018. PLoS Pathog. 14(1):e1006823. PMID: 29304174.
  •   Dembowski et al. 2017. PLoS Pathog. 13(1):e1006166. PMID: 28095497.
  •   Chen et al. 2007. J Virol. 81(16):8742-51. PMID: 17553899.
  •   Chen et al. 2007. J Virol. 81(16):8742-51. PMID: 17553899.
  •   A mutation in the human herpes simplex virus type 1 UL52 zinc finger motif results in defective primase activity but can recruit viral polymerase and support viral replication efficiently.