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Contributor Information

  • Name Nancy Hogg
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-CD11b (Integrin aM) [ICRF44]
  • Alternate names: Integrin Subunit Alpha M; Cell Surface Glycoprotein MAC-1 Subunit Alpha; Complement Component 3 Receptor 3 Subunit; CD11 Antigen-Like Family Member B; Leukocyte Adhesion Receptor MO1; CR-3 Alpha Chain; CD11B; CR3A; Macrophage Antigen Alpha Polypeptide); Neutrophil Adherence Receptor Alpha-M Subunit 3; Macrophage Antigen Alpha Polypeptide 3; Neutrophil Adherence Receptor 4; Antigen CD11b (P17) 3; CD11b Antigen; MAC-1; MAC1A; SLEB6; MO1A
  • Clone: ICRF44
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Primate
  • Host: Mouse
  • Molecular weight of the target: 160 kDa
  • Application: FACS ; IHC ; IP ; WB
  • Strain: Balb/c
  • Description: ICRF 44 blocks some functions of Mac-1.
  • Immunogen: Rheumatoid synovial cells and human monocytes.
  • Isotype: IgG1
  • Research area: Cell biology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Integrin alpha M (CD11b; Mac-1a subunit)
  • Target molecular weight: 160 kDa
  • Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha M (CD11B) is found in neutrophils, monocytes and NK cells. Patients lacking integrin aM molecules have immune deficiency symptoms and commonly subject to bacterial and fungal infections.

Application Details

  • Application: FACS ; IHC ; IP ; WB


  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C



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