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Contributor Information

  • Name Roland Wolf
  • Institute University of Dundee

Tool Details

  • Tool name: Anti-Cytochrome P450 2B1, 2B2 [b/e3]
  • Clone: b/e3
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Mouse ; Rat
  • Host: Mouse
  • Molecular weight of the target: 52 kDa
  • Application: ELISA ; IP ; WB
  • Description: The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. CYP2B1 and CYP2B2 are the major phenobarbital-inducible rat hepatic cytochromes P450s. This reagent was created through a research collaboration between Cancer Research UK and Syngenta Crop Protection AG.
  • Immunogen: Rat liver cytochromes p450 2B1 and 2B2
  • Isotype: IgG1
  • Research area: Cancer; Cell Signaling & Signal Transduction; Metabolism

  • For Research Use Only

Target Details

  • Target: Cytochromes P450 2B1, 2B2, CYP2B1, CYP2B2
  • Target molecular weight: 52 kDa
  • Target background: The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. CYP2B1 and CYP2B2 are the major phenobarbital-inducible rat hepatic cytochromes P450s. This reagent was created through a research collaboration between Cancer Research UK and Syngenta Crop Protection AG.

Application Details

  • Application: ELISA ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.84 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -20°C
  • Shipping conditions: Shipping at 4°C

Documentation

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  • Available on request

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References

  • •  Chanyshev et al. 2020. Toxicol Mech Methods. 30(8):562-569. PMID: 32508177.
  • •  Rencurel et al. 2005. J Biol Chem. 280(6):4367-73. PMID: 15572372.
  • •  AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.
  • •  Forrester et al. 1992. Biochem J. 281 ( Pt 2):359-68. PMID: 1736885.
  • •  Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.