Cat. #151067
Anti-cMyc [9E10]
Cat. #: 151067
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: c Myc epitope tag
Class: Monoclonal
Application: ChIP ; ELISA ; IHC ; IP ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Gerard Evan
Institute: University of California San Francisco
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-cMyc [9E10]
- Cancer: Breast cancer;Digestive / Gastrointestinal cancer;Gynaecologic cancer;Lung cancer
- Cancers detailed: Breast cancer;Broadly Applicable;Cervix;Colorectal;Lung;Stomach
- Research fields: Cancer;Cell biology;Genetics;Stem cell biology
- Clone: 9A
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ChIP ; ELISA ; IHC ; IP ; WB
- Description: Monoclonal antibody raised against sequence of c-Myc, a proto-oncogene heavily implicated in a variety of (hematopoietic) cancers, which has been used in cancer research to detect and understand the distribution of the c-Myc oncogene product.
- Immunogen: Synthetic peptide (AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA - 32 aa) corresponding to 408-439 of Human c-Myc conjugated to KLH.
- Immunogen uniprot id: P01106
- Isotype: IgG1 kappa
- Myeloma used: Sp2/0-Ag14
Target Details
- Target: c Myc epitope tag
- Target background: Anti c-Myc is raised against the proto-oncogene c-Myc, analogous to the avian v-Myc gene a very strong proto-oncogene often found to be upregulated in cancer. Aberrant and constitutive expression of c-Myc has been particularly implicated in the upregulation of genes involved in cellular proliferation and has been identified in cancers including carcinoma of cervix, colon, breast, lung and stomach, plus a translocation leading to Burkitt's lymphoma. The gene product of c-Myc (p62) is upregulat...
Applications
- Application: ChIP ; ELISA ; IHC ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Dry ice
Related Tools
- Related tools: K14MycER Mouse ; Anti-cMyc [9E11] ; Anti-cMyc, Recombinant [9E10]
References
- Si et al. 2018. Int J Biol Sci. 14(2):165-177. PMID: 29483835.
- Oh et al. 2018. Cell Rep. 25(7):1681-1692.e4. PMID: 30428339.
- Aldon et al. 2018. Cell Rep. 24(12):3324-3338.e5. PMID: 30232012.
- Rodrguez-Escudero et al. 2018. Sci Rep. 8(1):7732. PMID: 29769614.
- Mateos-Gomez et al. 2015. Nature. 518(7538):254-7. PMID: 25642960.
- Mammalian polymerase promotes alternative NHEJ and suppresses recombination.
- Zhang et al. 2014. Genes Dev. 28(8):829-34. PMID: 24736842.
- The diab...
