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Contributor Information

  • Name Gerard Evan
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-cMyc [9E11]
  • Clone: [9E11]
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Cervix; Colorectal; Breast; Lung; Stomach; Broadly Applicable
  • Application: ChIP ; FACS ; IHC ; IP ; WB
  • Strain: Balb/c
  • Description: The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-Myc is expressed in proliferating tissues and increased c-Myc expression is found in many cancers. N-Myc is amplified in a proportion of neuroblastoma patients.
  • Immunogen: Residues 408-420. AEEQKLISEEDL.
  • Isotype: IgG2a
  • Research area: Cancer; Cell Cycle; Epigenetics & Nuclear Signalling; Stem Cell Biology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: cMyc
  • Target background: The c-Myc and N-Myc oncogenes are members of the Myc family of transcription factors that regulate cell proliferation and apoptosis. c-Myc is expressed in proliferating tissues and increased c-Myc expression is found in many cancers. N-Myc is amplified in a proportion of neuroblastoma patients.

Application Details

  • Application: ChIP ; FACS ; IHC ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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  • Available on request

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References

  • •  Mittal et al. 2013. PLoS One. 8(8):e70352. PMID: 23936412.
  • •  Role of CTLA4 in the proliferation and survival of chronic lymphocytic leukemia.
  • •  Mirzaei et al. 2013. Proc Natl Acad Sci U S A. 110(9):3645-50. PMID: 23388641.
  • •  Systematic measurement of transcription factor-DNA interactions by targeted mass spectrometry identifies candidate gene regulatory proteins.
  • •  Keyhanfar et al. 2007. Biochem J. 401(1):269-77. PMID: 16981855.
  • •  Precise mapping of an IGF-I-binding site on the IGF-1R.
  • •  Halme et al. 2004. Cell. 116(3):405-15. PMID: 15016375.
  • •  Genetic and epigenetic regulation of the FLO gene family generates cell-surface variation in yeast.
  • •  Kari et al. 1986. J Virol. 60(2):345-52. PMID: 3021969.
  • •  Characterization of monoclonal antibodies reactive to several biochemically distinct human cytomegalovirus glycoprotein complexes.