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Contributor Information

  • Name Roland Wolf
  • Institute University of Dundee

Tool Details

  • Tool name: Anti-Cytochrome P450 3A1 [P6]
  • Clone: P6
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Rat
  • Host: Mouse
  • Application: ELISA ; FACS ; WB
  • Description: The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.
  • Immunogen: Rat liver cytochrome P450 3A1
  • Isotype: IgG1
  • Research area: Cancer; Cell Signaling & Signal Transduction; Metabolism

  • For Research Use Only

Target Details

  • Target: Cytochrome P450 3A1, CYP3A1
  • Target background: The CYP2 family are part of the microsomal drug metabolising system that is responsible for oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.

Application Details

  • Application: ELISA ; FACS ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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  • Available on request

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References

  • •  Probert et al. 2014. Toxicol Sci. 137(2):350-70. PMID: 24235770.
  • •  Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies.
  • •  Hu et al. 2011. Drug Metab Dispos. 39(3):419-25. PMID: 21135265.
  • •  Opposite effect of diabetes mellitus induced by streptozotocin on oral and intravenous pharmacokinetics of verapamil in rats.
  • •  Matuskova et al. 2009. Neuro Endocrinol Lett. 30 Suppl 1:41-5. PMID: 20027143.
  • •  Influence of probiotics on rat liver biotransformation enzymes.