Product Image

Contributor Information

  • Name Lionel Crawford
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-p53 [Pab 1104]
  • Clone: Pab 1104
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Broadly Applicable
  • Application: IHC ; IP
  • Strain: Balb/c
  • Description: PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104.
  • Immunogen: A slice of gel containing p53 homogenised in PBS. The p53 was extracted from the human SV40-transformed fibroblast cell line SV80 and purified by immunoprecipitation and SDS gel electrophoresis.
  • Isotype: IgM
  • Research area: Apoptosis and Programmed Cell Death; Cancer; Cell Cycle; DNA Damage and Repair; Epigenetics & Nuclear Signalling
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: p53
  • Target background: PAb1104 has distinct, intrinsic activities towards both p53 and SV40 large T-antigen. Only a subset of T-antigen is bound by PAb1104.

Application Details

  • Application: IHC ; IP

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

    Download Icon
    Download Icon
    Download Icon
    Download Icon
  • Available on request

Related Tools

Product Image

Anti-Lactase [mlac5]

#151690
Product Image

Anti-alpha E2 integrin (dendritic cells) [OX62]

#156603
Product Image

Anti-CD200 ligand [OX102]

#156531

References

  • •  Nayak et al. 2007. Cancer Res. 67(12):5831-9. PMID: 17575151.
  • •  Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs.
  • •  Leppard et al. 1984. J Virol. 50(2):457-64. PMID: 6323746.
  • •  An oligomeric form of simian virus 40 large T-antigen is immunologically related to the cellular tumor antigen p53.
  • •  Leppard et al. 1983. EMBO J. 2(9):1457-64. PMID: 11892796.
  • •  Monoclonal antibodies displaying a novel species specificity for the primate transformation-related protein, p53.