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Contributor Information

  • Name John Kemshead
  • Institute Institute of Child Health

Tool Details

  • Tool name: Anti-L1CAM [UJ181.4]
  • Clone: UJ181.4
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 220-240 kDa
  • Application: IHC ; IP ; WB
  • Strain: Balb/c
  • Description: Used in diagnosis of primitive neuroectodermal tumours. Binds to tumours of neural and glial origin and does not bind to paediatric or adult brain. Used for bone marrow purging and intrathecal targeting
  • Immunogen: 16 week human foetal brain.
  • Isotype: IgG1
  • Research area: Adhesion ; Cell Signaling & Signal Transduction ; Neurobiology
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: L1 cell adhesion molecule (L1CAM; CD171)
  • Target molecular weight: 220-240 kDa
  • Target background: Used in diagnosis of primitive neuroectodermal tumours. Binds to tumours of neural and glial origin and does not bind to paediatric or adult brain. Used for bone marrow purging and intrathecal targeting

Application Details

  • Application: IHC ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

  • Available on request

References

  •   Garson.JA. 1983. MD Thesis. Birmingham
  •   Bourne et al. 1989. Hybridoma. 8(4):415-26. PMID: 2550359.
  •   Monoclonal antibodies M340 and UJ181.4 recognize antigens associated with primitive neuroectodermal tumours/tissues.
  •   Coakham et al. 1985. J Clin Pathol. 38(2):165-73. PMID: 3881481.
  •   Immunohistological diagnosis of central nervous system tumours using a monoclonal antibody panel.
  •   Kemshead et al. 1983. Int J Cancer. 31(2):187-95. PMID: 6826247.
  •   Monoclonal antibody UJ 127:11 detects a 220,000-240,000 kdal. glycoprotein present on a sub-set of neuroectodermally derived cells.