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Contributor Information

  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-Cdc6 [cdc6 9H8/5]
  • Alternate names: Cell Division Cycle 6; Cdc18-Related Protein; CDC6-Related Protein; P62(Cdc6); HsCDC18; CDC18L; HsCDC6; CDC6 Cell Division Cycle 6 Homolog
  • Clone: cdc6 9H8/5
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Saccharomyces cerevisiae
  • Host: Mouse
  • Application: IHC ; IP ; WB
  • Description: Cdc6 is essential for assembling the pre-replicative complex that forms at origins of DNA replication in the G1 phase of the cell cycle in budding yeast (S. cerevisiae).
  • Immunogen: cdc6 from S.Cerevisiae.
  • Isotype: IgG1
  • Research area: Cell Cycle; Epigenetics & Nuclear Signalling

  • For Research Use Only

Target Details

  • Target: Cell-division cycle protein 6 (cdc6)
  • Target background: Cdc6 is essential for assembling the pre-replicative complex that forms at origins of DNA replication in the G1 phase of the cell cycle in budding yeast (S. cerevisiae).

Application Details

  • Application: IHC ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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  • Available on request

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References

  • •  Evrin et al. 2013. Nucleic Acids Res. 41(5):3162-72. PMID: 23376927.
  • •  A yeast GSK-3 kinase Mck1 promotes Cdc6 degradation to inhibit DNA re-replication.
  • •  Ikui et al. 2012. PLoS Genet. 8(12):e1003099. PMID: 23236290.
  • •  Zhang et al. 2007. Cancer Res. 67(8):3827-34. PMID: 17440097.
  • •  Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia.
  • •  Perkins et al. 2001. EMBO J. 20(17):4836-45. PMID: 11532947.
  • •  Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.
  • •  Donovan et al. 1997. Proc Natl Acad Sci U S A. 94(11):5611-6. PMID: 9159120.
  • •  Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast.