Product Image

Contributor Information

  • Name Helen Turley
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-BLM [BFL 103]
  • Clone: BFL 103
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: WB ; ELISA ; IHC ; IF ; WB
  • Strain: Balb/c
  • Description: BLM is the product of the Blooms syndrome gene and belongs to the RecQ family of DNA helicases. BLM is associated with an increase in the incidence of many types of cancer at an early age.
  • Immunogen: Recombinant Full Length Bloom's Protein
  • Isotype: IgG1
  • Research area: DNA Damage and Repair
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Bloom's Syndrome Protein (BLM)
  • Target background: BLM is the product of the Blooms syndrome gene and belongs to the RecQ family of DNA helicases. BLM is associated with an increase in the incidence of many types of cancer at an early age.

Application Details

  • Application: WB ; ELISA ; IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

  • Available on request

References

  •   Chen et al. 2019. Mol Med Rep. 19(6):4819-4831. PMID: 30957187.
  •   Zhu et al. 2008. J Biol Chem. 283(43):29405-15. PMID: 18708356.
  •   Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification.
  •   Turley et al. 2001. Br J Cancer. 85(2):261-5. PMID: 11461087.
  •   The distribution and expression of the Bloom's syndrome gene product in normal and neoplastic human cells.
  •   Wu et al. 2000. J Biol Chem. 275(13):9636-44. PMID: 10734115.
  •   The Bloom's syndrome gene product interacts with topoisomerase III.