- Name Paul Crocker
- Institute University of Dundee
Tool name: Anti-SIGLEC5 [1A5]
Alternate names: Sialic Acid Binding Ig Like Lectin 5; Obesity-Binding Protein 2; OB-Binding Protein 2; CD33 Antigen-Like 2; SIGLEC-5; CD33L2; OBBP2; Sialic Acid-Binding Immunoglobulin-Like Lectin 5; CD17 Antigen;
Tool type: Antibodies
Tool sub-type: Primary antibody
Application: IHC ; ELISA ; FACS ; IHC ; IF ; IP ; Fn ; WB
Description: The Siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Siglec5 (CD170) is a member of the recently-described human CD33-related siglec subgroup of sialic acid binding Ig-like lectins and is expressed on myeloid cells of the hemopoietic system. Similar to other CD33- related siglecs, Siglec-5 contains two tyrosine based motifs in its cytoplasmic tails implicated in signalling functions. The antibody cross reacts with Siglec14.
Immunogen: Siglec-5-Fc protein, containing entire extracellular region of siglec-5 fused with the Fc region of human IgG1
Research area: Adhesion ; Cell Type or Organelle Marker ; Immunology
Myeloma used: Sp2/0-Ag14
- For Research Use Only
- • Angata et al. 2006. FASEB J. 20(12):1964-73. PMID: 17012248.
- • Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates.
- • Nguyen et al. 2006. Proc Natl Acad Sci U S A. 103(20):7765-70. PMID: 16682635.
- • Loss of Siglec expression on T lymphocytes during human evolution.
- • Avril et al. 2005. J Biol Chem. 280(20):19843-51. PMID: 15769739.
- • Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation.
- • Connolly et al. 2002. Br J Haematol. 119(1):221-38. PMID: 12358929
- • Human Siglec-5: tissue distribution, novel isoforms and domain specificities for sialic acid-dependent ligand interactions.
- • Cornish et al. 1998. Blood. 92(6):2123-32. PMID: 9731071.
- • Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33.