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Contributor Information

  • Name Bill Gullick
  • Institute Imperial Cancer Research Fund

Tool Details

  • Tool name: Anti-RIP140 [6D7]
  • Clone: 6D7
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Rat
  • Host: Mouse
  • Application: ChIP ; ELISA ; IF ; IP ; WB
  • Immunogen: Recombinant human RIP140 GST fusion protein
  • Research area: Cell Signaling & Signal Transduction ; Epigenetics & Nuclear Signalling

  • For Research Use Only

Target Details

  • Target: RIP140
  • Target background: RIP140 is a ligand-dependent corepressor for most nuclear receptors, and functions through interaction with their AF2 activation domains. Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors.

Application Details

  • Application: ChIP ; ELISA ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C
  • Mycoplasma free: Yes

Documentation

  • Available on request

References

  •   Foulds et al. 2013. Mol Cell. 51(2):185-99. PMID: 23850489.
  •   Proteomic analysis of coregulators bound to ERa on DNA and nucleosomes reveals coregulator dynamics.
  •   Poliandri et al. 2011. J Biol Rhythms. 26(3):187-99. PMID: 21628546.
  •   Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140).
  •   Hallberg et al. 2008. Mol Cell Biol. 28(22):6785-95. PMID: 18794372.
  •   A Fn interaction between RIP140 and PGC-1alpha regulates the expression of the lipid droplet protein CIDEA.
  •   Herzog et al. 2007. Mol Endocrinol. 21(11):2687-97. PMID: 17684114.
  •   Kiskinis et al. 2007. EMBO J. 26(23):4831-40. PMID: 17972916.
  •   RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes.
  •   The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor.