ANTIBODIES

Contributor Information
- Name Karen Pulford
- Institute University of Oxford
Tool Details
- Tool name: Anti-CD22 [4KB71]
- Clone: 4KB71
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Molecular weight of the target:
- Application: IHC
- Description: SIGLEC2 is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC2 is strongly expressed in hairy cell leukaemias.
- Immunogen: Hairy cell leukaemia cells
- Isotype: IgG
- Research area: Cell biology; Cancer; Cell signaling and signal transduction; Immunology; Stem cell biology
- Myeloma used: P3/NS1/1-Ag4.1
- For Research Use Only
Target Details
- Target: CD22
- Target molecular weight:
- Target background: SIGLEC2 is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC2 is strongly expressed in hairy cell leukaemias.
Application Details
- Application: IHC
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -80ðC
- Shipping conditions: Shipping at 4ðC
Related Tools
References
- • Mason et al. 1987. Blood. 69(3):836-40. PMID: 3101766.
- • Value of monoclonal anti-CD22 (p135) antibodies for the detection of normal and neoplastic B lymphoid cells.