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Contributor Information

  • Name Karen Pulford
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-CD22 [4KB71]
  • Clone: 4KB71
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target:
  • Application: IHC
  • Description: SIGLEC2 is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC2 is strongly expressed in hairy cell leukaemias.
  • Immunogen: Hairy cell leukaemia cells
  • Isotype: IgG
  • Research area: Cell biology; Cancer; Cell signaling and signal transduction; Immunology; Stem cell biology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: CD22
  • Target molecular weight:
  • Target background: SIGLEC2 is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC2 is strongly expressed in hairy cell leukaemias.

Application Details

  • Application: IHC

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -80°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Mason et al. 1987. Blood. 69(3):836-40. PMID: 3101766.
  • •  Value of monoclonal anti-CD22 (p135) antibodies for the detection of normal and neoplastic B lymphoid cells.