ANTIBODIES
Contributor Information
- Name David Elliott
- Institute Newcastle University
Tool Details
- Tool name: Anti-ASPP1 [ASPP1]
- Clone: ASPP1
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Polyclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Sheep
- Molecular weight of the target:
- Application: IF ; IP ; WB
- Description: iASPP1 inhibits the proaptotic functions of ASPP1 and p53.
- Immunogen: Amino acids from human ASPP1 357-532
- Research area: Cancer ; Stem Cell Biology
- For Research Use Only
Target Details
- Target: ASPP1
- Target molecular weight:
- Target background: Stimulating protein of p53 (ASPP) contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. There are three known types of ASPP: ASPP1, ASPP2 and iASPP1.
Application Details
- Application: IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Storage conditions: -15°C to -25°C
- Shipping conditions: Shipping at 4°C
Documentation
- Available on request
Related Tools
References
- • Thornton et al. 2006. Oncogene. 25(22):3104-12. PMID: 16474851.
- • The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo.
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