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Contributor Information

  • Name David Elliott
  • Institute Newcastle University

Tool Details

  • Tool name: Anti-ASPP1 [ASPP1]
  • Clone: ASPP1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Sheep
  • Molecular weight of the target:
  • Application: IF ; IP ; WB
  • Description: iASPP1 inhibits the proaptotic functions of ASPP1 and p53.
  • Immunogen: Amino acids from human ASPP1 357-532
  • Research area: Cancer ; Stem Cell Biology

  • For Research Use Only

Target Details

  • Target: ASPP1
  • Target molecular weight:
  • Target background: Stimulating protein of p53 (ASPP) contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. There are three known types of ASPP: ASPP1, ASPP2 and iASPP1.

Application Details

  • Application: IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

  • Available on request

References

  •   Thornton et al. 2006. Oncogene. 25(22):3104-12. PMID: 16474851.
  •   The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo.