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Contributor Information

  • Name Ayham Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-Cytochrome P450 26A1 [F27P6A1]
  • Clone: F27P6A1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 18.4 kDa
  • Application: ELISA ; IHC ; WB
  • Strain: Balb/c
  • Description: Mutations in CYP26A1 are associated with caudal agenesis and spina bifida. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryo.
  • Immunogen: Ovalbumin-conjugated synthetic peptide PARFTHFHGE (C-terminal sequence)
  • Isotype: IgG2b kappa
  • Research area: Cancer ; Cell Signaling & Signal Transduction ; Metabolism
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: CYP26A1 Cytochrome P450 26A1 (Retinoic acid-metabolizing cytochrome) (P450 retinoicacid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase).
  • Target molecular weight: 18.4 kDa
  • Target background: Mutations in CYP26A1 are associated with caudal agenesis and spina bifida. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryo.

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

  • Available on request

References

  •   Stoney et al. 2015. Brain Struct Funct. :. PMID: 26374207.
  •   Expression of the retinoic acid catabolic enzyme CYP26B1 in the human brain to maintain signaling homeostasis.
  •   Brown et al. 2014. PLoS One. 9(3):e90776. PMID: 24608339.
  •   The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer.
  •   Downie et al. 2005. Clin Cancer Res. 11(20):7369-75. PMID: 16243809.
  •   Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
  •   Kumarakulasingham et al. 2005. Clin Cancer Res. 11(10):3758-65. PMID: 15897573.
  •   Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.