- Name Carl Blobel
- Institute Hospital for Special Surgery
Tool name: Anti-ADAM9 [9MO]
Tool type: Antibodies
Tool sub-type: Primary antibody
Molecular weight of the target: ~84 kDa (mature form), 115 kDa (pro-form)
Description: ADAM9 encodes disintegrin and metalloprotease (ADAM) domain 9, which is a member of the ADAM protein family. Members of this family are membrane- anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell- cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The member encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.
Immunogen: GST-cyto corresponding to the cytoplasmic domain of murine ADAM9
Research area: Cancer; Cell signaling and signal transduction
- For Research Use Only
- • Guaiquil et al. 2009. Mol Cell Biol. 29(10):2694-703. PMID: 19273593.
- • Peduto et al. 2005. Cancer Res. 65(20):9312-9. PMID: 16230393.
- • Roghani et al. 1999. J Biol Chem. 274(6):3531-40. PMID: 9920899.
- • ADAM9 is involved in pathological retinal neovascularization.
- • Critical function for ADAM9 in mouse prostate cancer.
- • Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity.
- • Weskamp et al. 1996. J Cell Biol. 132(4):717-26. PMID: 8647900.
- • MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.