Product Image

Contributor Information

  • Name Carl Blobel
  • Institute Hospital for Special Surgery

Tool Details

  • Tool name: Anti-ADAM9 [9MO]
  • Clone: 9MO
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Polyclonal
  • Conjugate: Unconjugated
  • Reactivity: Mouse
  • Host: Rabbit
  • Molecular weight of the target: ~84 kDa (mature form), 115 kDa (pro-form)
  • Application: WB
  • Description: ADAM9 encodes disintegrin and metalloprotease (ADAM) domain 9, which is a member of the ADAM protein family. Members of this family are membrane- anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell- cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The member encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.
  • Immunogen: GST-cyto corresponding to the cytoplasmic domain of murine ADAM9
  • Research area: Cancer; Cell signaling and signal transduction

  • For Research Use Only

Target Details

  • Target: ADAM9
  • Target molecular weight: ~84 kDa (mature form), 115 kDa (pro-form)
  • Target background: ADAM9 encodes disintegrin and metalloprotease (ADAM) domain 9, which is a member of the ADAM protein family. Members of this family are membrane- anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell- cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The member encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

Application Details

  • Application: WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: Whole serum
  • Storage conditions: -20°C
  • Shipping conditions: Shipping at 4°C

Documentation

Related Tools

Product Image

Anti-CD9 [P1/33/2] rAb

#154820
Product Image

Anti-TCR CBeta1 [JOVI.1] mAb

#151289
Product Image

Anti-Phospho-Rb (Ser608) [51B7]

#153409

References

  • •  Guaiquil et al. 2009. Mol Cell Biol. 29(10):2694-703. PMID: 19273593.
  • •  Peduto et al. 2005. Cancer Res. 65(20):9312-9. PMID: 16230393.
  • •  Roghani et al. 1999. J Biol Chem. 274(6):3531-40. PMID: 9920899.
  • •  ADAM9 is involved in pathological retinal neovascularization.
  • •  Critical function for ADAM9 in mouse prostate cancer.
  • •  Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity.
  • •  Weskamp et al. 1996. J Cell Biol. 132(4):717-26. PMID: 8647900.
  • •  MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.