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Contributor Information

  • Institute A*STAR Accelerate Technologies Pte Ltd

Tool Details

  • Tool name: Anti-SΔ10 [1A9]
  • Clone: 1A9
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Virus
  • Host: Mouse
  • Application: FACS ; Fn ; WB
  • Description: Severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes for four structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E). The S protein, which forms morphologically characteristic projections on the virion surface, is responsible for binding to cellular receptor and mediating the fusion between viral and cellular membranes. Both of these processes are critical for virus entry into host cells. The SΔ10 is a fragment containing residues from 1029 to 1129 of the S protein, which is a domain that is crucial for the fusion process.
  • Immunogen: GST-S?10 fusion protein
  • Isotype: IgG1 kappa
  • Research area: Virology
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: S protein of the SARS coronavirus
  • Target background: Severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes for four structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E). The S protein, which forms morphologically characteristic projections on the virion surface, is responsible for binding to cellular receptor and mediating the fusion between viral and cellular membranes. Both of these processes are critical for virus entry into host cells. The SΔ10 is a fragment containing residues from 1029 to 1129 of the S protein, which is a domain that is crucial for the fusion process.

Application Details

  • Application: FACS ; Fn ; WB

Handling

  • Format: Liquid
  • Concentration: 1mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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  • Available on request

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References

  • •  Ng et al. 2014. PLoS One. 9(7):e102415. PMID: 25019613.
  • •  Substitution at aspartic acid 1128 in the SARS coronavirus spike glycoprotein mediates escape from a S2 domain-targeting neutralizing monoclonal antibody.
  • •  Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996.
  • •  Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.