ANTIBODIES
Contributor Information
- Name Julin Wong ; David Lane
- Institute A*STAR Accelerate Technologies Pte Ltd
Tool Details
- Tool name: Anti-c-Met [13]
- Clone: 13
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: FACS ; IF ; IP ; WB
- Description: c-Met is a tyrosine receptor kinase which is activated by its ligand, the hepatocyte growth factor. Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met is abnormally activated in many tumour types. Aberrant c-Met activation was found to induce tumour development, tumour cell migration and invasion, and the worst and final step in cancer progression, metastasis.
- Immunogen: Bacterially expressed human c-Met alpha chain
- Isotype: IgG1 kappa
- Research area: Cancer; Cell signaling and signal transduction; Genetics
- Myeloma used: Sp2/0-Ag14
- For Research Use Only
Target Details
- Target: c-Met, cMet
- Target background: c-Met is a tyrosine receptor kinase which is activated by its ligand, the hepatocyte growth factor. Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met is abnormally activated in many tumour types. Aberrant c-Met activation was found to induce tumour development, tumour cell migration and invasion, and the worst and final step in cancer progression, metastasis.
Application Details
- Application: FACS ; IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15Ă°C to -25Ă°C
- Shipping conditions: Shipping at 4Ă°C
Documentation
Related Tools
References
- • Wong et al. 2013. Oncotarget. 4(7):1019-36. PMID: 23859937.
- • Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth.
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