Product Image

Contributor Information

  • Name Mike Horton
  • Institute Queen Mary University of London

Tool Details

  • Tool name: Anti-CD13 [22A5]
  • Alternate names: Alanyl Aminopeptidase; Membrane; Microsomal Aminopeptidase; Aminopeptidase M; Myeloid Plasma Membrane Glycoprotein CD13; GP15; CD13; PEPN
  • Clone: 22A5
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: FACS ; IHC ; IP
  • Strain: Balb/c
  • Description: Aminopeptidase N (CD13) is a cell-surface metalloprotease involved in the metabolism of regulatory peptides. 22A5 may be useful for the diagnosis and immunophenotyping of leukaemia.
  • Immunogen: A cell suspension containing osteoclasts from osteoclastomas.
  • Isotype: IgG2a kappa
  • Research area: Cancer; Cell Type or Organelle Marker; Metabolism; Protein Degradation; Stem Cell Biology

  • For Research Use Only

Target Details

  • Target: Aminopeptidase N (CD13)
  • Target background: Aminopeptidase N (CD13) is a cell-surface metalloprotease involved in the metabolism of regulatory peptides. 22A5 may be useful for the diagnosis and immunophenotyping of leukaemia.

Application Details

  • Application: FACS ; IHC ; IP

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

    Download Icon
    Download Icon
    Download Icon
    Download Icon
  • Available on request

Related Tools

Product Image

Anti-SNAP-25 [SP14]

#158425
Product Image

Anti-Homogalacturonan [LM18]

#157921
Product Image

Anti-EGFP (Rat) "Brainbow"

#155258

References

  • •  Murray et al. 1995. Leuk Lymphoma. 17(5-6):501-8. PMID: 7549844.
  • •  Immunocytochemical studies of an antigen in a human T-cell lymphoma line (Jurkat) recognized by certain monoclonal antibodies to CD-13 (aminopeptidase-N).
  • •  van Hal et al. 1994. J Immunol. 153(6):2718-28. PMID: 7915741.
  • •  Potential indirect anti-inflammatory effects of IL-4. Stimulation of human monocytes, macrophages, and endothelial cells by IL-4 increases aminopeptidase-N activity (CD13
  • •  EC 3.4.11.2).
  • •  Ashmun et al. 1990. Blood. 75(2):462-9. PMID: 1967220.
  • •  Metalloprotease activity of CD13/aminopeptidase N on the surface of human myeloid cells.
  • •  Look et al. 1989. J Clin Invest. 83(4):1299-307. PMID: 2564851.
  • •  Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N.
  • •  Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.
  • •  Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.