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Contributor Information

  • Name Julia Bodmer
  • Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details

  • Tool name: Anti-HLA-DR [TAL 16.1]
  • Clone: TAL 16.1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 29 kDa
  • Application: ELISA ; FACS ; IHC ; WB
  • Description: Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 16.1 is useful for distinguishing DR1 homozygotes from DR1, DR103 heterozygotes.
  • Immunogen: Mouse L cell transfected with a Human HLA Class II (HLADRB5*0101) gene
  • Isotype: IgG2a
  • Research area: Immunology
  • Myeloma used: NS0

  • For Research Use Only

Target Details

  • Target: Human leukocyte antigens DR16, 103, 11, 12, 13, 8, 7, 4 (Dw10 only), DR51
  • Target molecular weight: 29 kDa
  • Target background: Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 16.1 is useful for distinguishing DR1 homozygotes from DR1, DR103 heterozygotes.

Application Details

  • Application: ELISA ; FACS ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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  • Available on request

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References

  • •  Sadler et al. 1993. Tissue Antigens. 41(1):42-6. PMID: 7681224.
  • •  The monoclonal antibody TAL16.1 recognizes the aspartic acid residue at position 70 in DRB gene products.
  • •  Altmann et al. 1990. Immunogenetics. 32(1):51-5. PMID: 1695613.
  • •  Fine mapping of HLA class II monoclonal antibody specificities using transfected L cells.