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Contributor Information

  • Name Ayham Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-Cytochrome P450 1B1 [5E2]
  • Clone: 500
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Rat
  • Host: Mouse
  • Molecular weight of the target: 52 kDa
  • Application: ELISA ; IHC ; WB
  • Strain: Balb/c
  • Description: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development. CYP1B1 is upregulated in tumour cells and is a therapeutic target
  • Immunogen: Ovalbumin-conjugated synthetic peptide - PENFDPARFLDKDGL
  • Isotype: IgG1 kappa
  • Research area: Cancer; Cell Signaling & Signal Transduction; Metabolism

  • For Research Use Only

Target Details

  • Target: Cytochrome P450, Family 1, Subfamily B, Polypeptide 1, CYP1B1
  • Target molecular weight: 52 kDa
  • Target background: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development. CYP1B1 is upregulated in tumour cells and is a therapeutic target

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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  • Available on request

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References

  • •  McFadyen et al. 1999. J Histochem Cytochem. 47(11):1457-64. PMID: 10544218.
  • •  Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1.