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Contributor Information

  • Name Helen Turley
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-LONP1 [LON20/H1]
  • Alternate names: hLON, hLON ATP dependent protease, LON, LONP1, lon peptidase 1, mitochondrial, LON protease, Lon protease homolog, Lon protease like protein, Lon protease-like protein
  • Clone: LON20/H1
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 106 kDa
  • Application: ELISA ; IHC ; WB
  • Description: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner.
  • Immunogen: KLH-peptide conjugate - N-CEKDDKDAIEEKFRERLKE-C
  • Isotype: IgG
  • Research area: Cancer; Epigenetics & Nuclear Signalling; Metabolism

  • For Research Use Only

Target Details

  • Target: Human LON protease
  • Target molecular weight: 106 kDa
  • Target background: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner.

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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  • Available on request

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References

  • •  Cameron Edward Snell PhD thesis, (2013). Mitochondrial modulators of hypoxia-related pathways in tumours. DPhil. University of Oxford.
  • •  Snell et al., 2016. Targeting the mitochondrial Lon protease reduces aerobic glycolysis and HIF-1a stabilisation in tumour cells. Submitted for publication.