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Contributor Information

  • Name Karen Pulford
  • Institute University of Oxford

Tool Details

  • Tool name: Anti-CD11b [2LPM19c]
  • Alternate names: CD11b, Integrin alpha M, Integrin aM, Mac-1 a subunit, C3bi receptor, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor
  • Clone: 2LPM19c
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 127 kDa
  • Application: FACS ; IHC
  • Description: CD11b, also known as Integrin alpha M, is found in neutrophils, monocytes and Natural Killer (NK) cells. CD11b plays a role in chemotaxis, apoptosis and phagocytosis. It is absent in Leukocyte Adhesion Deficiency (LAD-1) and is a target for anti-inflammatory drug therapies. CD11b is part of the CD11b/CD18 heterodimer (Mac-1 a, Mß2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. In humans, CD11b is strongly expressed on myeloid cells and weakly expressed on NK cells and some activated lymphocytes as well as on microglia in the brain.
  • Immunogen: Purified C3bi receptor
  • Isotype: IgG1 kappa
  • Research area: Adhesion ; Apoptosis and Programmed Cell Death ; Cell Type or Organelle Marker ; Cell Signaling & Signal Transduction ; Immunology ; Neurobiology ; Stem Cell Biology
  • Myeloma used: P3/NS1/1-Ag4.1

  • For Research Use Only

Target Details

  • Target: Cluster of Differentiation 11b (CD11b)
  • Target molecular weight: 127 kDa
  • Target background: CD11b, also known as Integrin alpha M, is found in neutrophils, monocytes and Natural Killer (NK) cells. CD11b plays a role in chemotaxis, apoptosis and phagocytosis. It is absent in Leukocyte Adhesion Deficiency (LAD-1) and is a target for anti-inflammatory drug therapies. CD11b is part of the CD11b/CD18 heterodimer (Mac-1 a, M?2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. In humans, CD11b is strongly expressed on myeloid cells and weakly expressed on NK cells and some activated lymphocytes as well as on microglia in the brain.

Application Details

  • Application: FACS ; IHC

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

  • Available on request

References

  •   Kupatt et al. 2000. Arterioscler Thromb Vasc Biol. 20(10):2226-32. PMID: 11031208.
  •   c7E3Fab reduces postischemic leukocyte-thrombocyte interaction mediated by fibrinogen. Implications for myocardial reperfusion injury.
  •   Violette et al. 1995. J Immunol. 155(6):3092-101. PMID: 7673724.
  •   Differences in the binding of blocking anti-CD11b monoclonal antibodies to the A-domain of CD11b.
  •   Diamond et al. 1993. J Cell Biol. 120(4):1031-43. PMID: 7679388.
  •   The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.