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Contributor Information

  • Name Ron Laskey
  • Institute University of Cambridge

Tool Details

  • Tool name: Anti-Myb [10A3]
  • Alternate names: MYB; C-myb_CDS; C-myb8B_CDS; C-myb protein (14 AA); C-myb1A_CDS; C-myb13A_CDS; Efg; Transcriptional activator Myb; C-myb; C-myb14A_CDS; Cmyb; Proto-oncogene c-Myb
  • Clone: 10A3
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Xenopus laevis ; Zebrafish
  • Host: Mouse
  • Molecular weight of the target: 55 kDa
  • Application: IP ; WB
  • Description: MYB / c-Myb is a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.
  • Immunogen: Recombinant v-myb protein
  • Isotype: IgG2a
  • Research area: Epigenetics; Haematopoesis

  • For Research Use Only

Target Details

  • Target: Xenopus MYB / c-Myb
  • Target molecular weight: 55 kDa
  • Target background: MYB / c-Myb is a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants.

Application Details

  • Application: IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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  • Available on request

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References

  • •  Benes et al. 2007. Leuk Res. 31(10):1421-31. PMID: 17624428.
  • •  Retinoic acid enhances differentiation of v-myb-transformed monoblasts induced by okadaic acid.