ANTIBODIES

CancerTools.org: The home for cancer research tools

Back

Anti-HIV gp41 [SAR1]

Cat. #153418

Tool name: Anti-HIV gp41 [SAR1]
Alternate names: Env antibody, Glycoprotein 41 antibody, gp41 antibody, Human Immunodeficiency Virus 1 antibody, TM antibody, Transmembrane protein antibody
Clone: SAR1
Tool type: Antibodies
Class: Monoclonal
Conjugate: Unconjugated
Reactivity: Virus
Host: Mouse
Application: ELISA ; Fn ; WB
Description: The envelope protein of human immunodeficiency virus type 1 (HIV-1) is synthesized as a gp160 polypeptide that is cleaved to form a non-covalently linked heterodimer; an external gp120 domain and a transmembrane anchoring gp41 domain. The monoclonal antibody SAR1 is a novel IgG that was raised by immunising mice with a plant virus chimera expressing the gp41 tail sequence GERDRDR. SAR1 recognizes gp41 expressed on the surface of infected cells, and binds to some, but not all, preparations of purified virions, suggesting that it may recognize non-infectious virions or degraded/immature forms of the envelope protein. SAR1 actively neutralized virus after it had attached to target cells but had little activity against free virions. Data suggest that SAR1 mediates post-attachment neutralization of virus bound to target cells by inhibiting virus-mediated fusion.
Immunogen: Mice were infected with Cowpea mosaic virus-HIV-1 gp41 chimera (30 ?g/ml) expressing the gp41 C-terminal sequence GERDRDR
Isotype: IgG2a kappa
Research area: Immunology; Virology
Myeloma used: Sp2/0-Ag14

Target: HIV-1 gp41 tail sequence GERDRDR
Target background: The envelope protein of human immunodeficiency virus type 1 (HIV-1) is synthesized as a gp160 polypeptide that is cleaved to form a non-covalently linked heterodimer; an external gp120 domain and a transmembrane anchoring gp41 domain. The monoclonal antibody SAR1 is a novel IgG that was raised by immunising mice with a plant virus chimera expressing the gp41 tail sequence GERDRDR. SAR1 recognizes gp41 expressed on the surface of infected cells, and binds to some, but not all, preparations of purified virions, suggesting that it may recognize non-infectious virions or degraded/immature forms of the envelope protein. SAR1 actively neutralized virus after it had attached to target cells but had little activity against free virions. Data suggest that SAR1 mediates post-attachment neutralization of virus bound to target cells by inhibiting virus-mediated fusion.

£ 300
This fee is applicable only for non-profit organizations

Quantity:

For any enquiries, please, contact us .