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Contributor Information

  • Name Ayham Alnabulsi
  • Institute Vertebrate Antibodies Limited

Tool Details

  • Tool name: Anti-PIWIL3 [Z83]
  • Alternate names: Anti-PIWIL3 antibody, HIWI3 antibody, Piwi like 3 antibody, PIWL3_HUMAN antibody
  • Clone: Z83
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Monoclonal
  • Purpose: Marker
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Cancer type: Ovarian
  • Application: ELISA ; IHC ; WB
  • Immunogen: Ovalbumin-conjugated synthetic peptide PNRSLSTRLFYL- peptide immunogen is identical in primates
  • Research area: Developmental Biology ; Epigenetics & Nuclear Signalling ; Stem Cell Biology

  • For Research Use Only

Target Details

  • Target: Piwi Like RNA-Mediated Gene Silencing 3
  • Target background: PIWIL3 may play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. PIWIL3 acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. PIWIL3 directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs may be involved in other processes during meiosis such as translation regulation.

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

  • Available on request