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Contributor Information

  • Name Ahmad Waseem
  • Institute Queen Mary University of London

Tool Details

  • Tool name: Anti-Cytokeratin 2e [LHK2E]
  • Alternate names: CK 2e antibody, Cytokeratin-2e antibody, Epithelial keratin-2e antibody, K2e antibody, Keratin type II cytoskeletal 2 epidermal antibody, Keratin-2 epidermis antibody, KRT2 antibody, KRT2A antibody, KRT2E antibody, Type-II keratin Kb2 antibody
  • Clone: LHK2E
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; WB
  • Strain: Balb/c
  • Description: The cytoskeleton in keratinocytes is a complex of highly homologous structural proteins derived from two families of type I and type II polypeptides. Keratin K2e is a type II polypeptide that is expressed in epidermis late in differentiation. K2e expression in skin is sensitive to keratinocyte activation but its up-regulation in oral lesions is a reflection of the degree of orthokeratinization.
  • Immunogen: C terminus of the K2e polypeptide (synthetic peptide NH2-GEAFGSSVTFSFR-COOH)
  • Isotype: IgM
  • Research area: Cancer; Cell Signaling & Signal Transduction
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: Keratin K2e
  • Target background: The cytoskeleton in keratinocytes is a complex of highly homologous structural proteins derived from two families of type I and type II polypeptides. Keratin K2e is a type II polypeptide that is expressed in epidermis late in differentiation. K2e expression in skin is sensitive to keratinocyte activation but its up-regulation in oral lesions is a reflection of the degree of orthokeratinization.

Application Details

  • Application: IHC ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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  • Available on request

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References

  • •  Bloor et al. 2003. Am J Pathol. 162(3):963-75. PMID: 12598329.
  • •  Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization.