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Contributor Information

Tool Details

  • Tool name: Anti-HuD [16C12]
  • Alternate names: ELAV-like protein 4
  • Clone: 16C12
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Rat ; Zebrafish
  • Host: Mouse
  • Application: ELISA ; IHC ; WB
  • Description: HuD, also known as ELAV-like protein 4, is a protein that in humans is encoded by the ELAVL4 gene. The HuD/ELAVL4 protein is an RNA-binding protein. HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity. The 16C12 monoclonal antibody is the reagent of choice to determine the expression of HuD (ELAVL4) by IHC or western blotting. It is known to react with human, mouse, rat, and zebrafish HuD. It was generated against a unique peptide found in HuD and does not bind to HuC, HeLN-1 or HuR
  • Immunogen: Synthetic peptide
  • Isotype: IgG2b
  • Research area: Developmental biology; Genetics; Neurobiology

  • For Research Use Only

Target Details

  • Target: HuD
  • Target background: HuD, also known as ELAV-like protein 4, is a protein that in humans is encoded by the ELAVL4 gene. The HuD/ELAVL4 protein is an RNA-binding protein. HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity. The 16C12 monoclonal antibody is the reagent of choice to determine the expression of HuD (ELAVL4) by IHC or western blotting. It is known to react with human, mouse, rat, and zebrafish HuD. It was generated against a unique peptide found in HuD and does not bind to HuC, HeLN-1 or HuR

Application Details

  • Application: ELISA ; IHC ; WB

Handling

  • Format: Liquid
  • Storage buffer:
  • Storage conditions:
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Burry et al. 2006. J Histochem Cytochem. 54(10):1129-38. PMID: 16801526.