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Contributor Information

  • Name Richard Aster
  • Institute Versiti Blood Research Institute

Tool Details

  • Tool name: Anti-Integrin Beta 3 (GPIIIa, CD61) [AP-2]
  • Alternate names: CD-61
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Host: Mouse
  • Application: ELISA ; FACS
  • Description: Glycoprotein IIb/IIIa, also known as integrin aIIb?Ÿ3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
  • Immunogen: Human platelet
  • Isotype: IgG1
  • Research area: Immunology

  • For Research Use Only

Target Details

  • Target: Integrin Beta 3 (GPIIIa, CD61) 
  • Target background: Glycoprotein IIb/IIIa, also known as integrin aIIb?Ÿ3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.

Application Details

  • Application: ELISA ; FACS

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Pidard et al. 1983. J Biol Chem. 258(20):12582-6. PMID: 6226659.
  • •  Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets.