ANTIBODIES
Contributor Information
- Name Richard Aster
- Institute Versiti Blood Research Institute
Tool Details
- Tool name: Anti-Integrin Beta 3a (GPIIIa, CD61) [AP-5]
- Alternate names: CD-61
- Tool type: Antibodies
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Molecular weight of the target: ~ 86-87 kDa
- Application: FACS ; IHC ; WB
- Description: Glycoprotein IIb/IIIa, also known as integrin aIIb?Â3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
- Immunogen: peptide
- Isotype: IgG1
- Research area: Immunology
- For Research Use Only
Target Details
- Target: Integrin Beta 3a (GPIIIa, CD61)ĂÂ
- Target molecular weight: ~ 86-87 kDa
- Target background: Glycoprotein IIb/IIIa, also known as integrin aIIb?Â3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
Application Details
- Application: FACS ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1mg/ml
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15°C to -25°C
- Shipping conditions: Shipping at 4°C
Documentation
- Available on request
Related Tools
References
- • Honda et al. 1995. J Biol Chem. 270(20):11947-54. PMID: 7538128.
- • Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit.
.svg)
Unit size: 
.svg)
.svg)
