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Contributor Information

  • Name Bruno Galy
  • Institute Deutsches Krebsforschungszentrum (DKFZ)- German Cancer Research Center

Tool Details

  • Tool name: Anti-IREB2 [IREB2-46-18-1]
  • Alternate names: Iron regulatory protein 2 (IREB2)
  • Clone: Xbio/DK/IREB2
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Mouse
  • Host: Rat
  • Application: ELISA ; IP ; WB
  • Immunogen: Full length His-tagged IREB2 of mouse origin, produced in E. coli
  • Research area: Cell Structure and Motility ; Metabolism ; Neurobiology

  • For Research Use Only

Target Details

  • Target: IREB2, Uniprot ID:Q811J3
  • Target background: Monoclonal antibody which binds IREB2, involved in iron homeostasis. Background and Research Application IREB2 (iron regulatory protein 2) is an RNA binding protein and a central regulator of cellular iron homeostasis. This protein regulates iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. In humans IREB2 polymorphism is linked to chronic obstructive pulmonary disease (CPOD), lung cancer and Alzheimer's disease. IREB2-null mice suffer from anaemia, abnormal body iron distribution, and neurodegeneration. IREB2 also plays various roles in cancer.

Application Details

  • Application: ELISA ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20°C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4°C
  • Mycoplasma free: Yes

Documentation

  • Available on request

References

  •   Not published yet (as of 08/08/2018)