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Contributor Information

  • Name Anders Elm Pedersen ; Mogens H Claesson
  • Institute University of Copenhagen

Tool Details

  • Tool name: Anti-eAg Antibody from X63 Fused CD19 B Cell Hybridoma (F8)
  • Clone: F8
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Description: Regulatory B cells (Bregs) have been shown to play a role in inflammatory bowel disease (IBD) in humans, as B cell depletion in patients with IBD tends to aggravate the disease. Furthermore it has been demonstrated that co-transfer of eAg-exposed B cells improves symptoms of experimental colitis in the T cell transfer model of colitis. This eAg-specific B cell hybridoma offers a unique tool to investigate the immune response towards eAg’s in experimental colitis, and potentially, in human IBD.
  • Research area: Other

  • For Research Use Only

Target Details

  • Target: Enteroantigen
  • Target background: Regulatory B cells (Bregs) have been shown to play a role in inflammatory bowel disease (IBD) in humans, as B cell depletion in patients with IBD tends to aggravate the disease. Furthermore it has been demonstrated that co-transfer of eAg-exposed B cells improves symptoms of experimental colitis in the T cell transfer model of colitis. This eAg-specific B cell hybridoma offers a unique tool to investigate the immune response towards eAg’s in experimental colitis, and potentially, in human IBD.

Application Details

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  In vitro cloning and regulatory potential of B cell hybridomas secreting entero-antigen specific antibody.