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Contributor Information

  • Name Lance Wells
  • Institute University of Georgia

Tool Details

  • Tool name: Anti-O-linked N-acetylglucosamine (O-GlcNAc) [5F6.G4]
  • Alternate names: O-GlcNAc
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Mammals
  • Host: Mouse
  • Application: ELISA ; WB
  • Immunogen: Synthetic peptide O-GlcNAc
  • Research area: Cell Signaling & Signal Transduction ; Metabolism ; Cancer ; Epigenetics & Nuclear Signalling ; Gene Expression ; Neurobiology

  • For Research Use Only

Target Details

  • Target: O-linked N-acetylglucosamine
  • Target background: The study of O-GlcNAc, a ubiquitous translation and transcription regulator which is found in a wide variety of proteins, is of great relevance to multiple chronic human and veterinary diseases. These include diabetes (and its effects in the heart, kidneys and eyes), cardiovascular disease, neurodegenerative disorders involving both plaque and tangle formation, inflammatory processes, liver disease, fibrosis, metabolic disorders and cancer. There is fast growing collection of evidence that O-GlcNAcylation plays a pivotal role in epigenetics.

Application Details

  • Application: ELISA ; WB

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

  • Available on request

References

  •   Rios et al. 2016. Angew Chem Int Ed Engl. 55(10):3387-92. PMID: 26822115.
  •   Synthetic Receptors for the High-Affinity Recognition of O-GlcNAc Derivatives.
  •   Teo et al. 2010. Nat Chem Biol. 6(5):338-43. PMID: 20305658.
  •   Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc.