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Contributor Information

  • Name Richard Meager
  • Institute University of Georgia

Tool Details

  • Tool name: Anti-?-ECS [11H7.C1.A2]
  • Alternate names: ?-ECS
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: E.coli ; Plant ; Saccharomyces
  • Host: Mouse
  • Application: ELISA ; IF ; WB
  • Description: Together with glutathione synthetase and phytochelatin synthetase, gamma-glutamyl Cys sythetase (Î?-ECS) is an enzyme involved in, and required for, synthesizing phytochelatins (PC). Î?-ECS is involved in the biosynthesis of Glutathione. PC are multidentate ligands that are able to form chelates with thio-reactive, “soft” metal cations such as Cd2+, Hg2+, and at least one oxoanion (AsO33-). In certain plants, deficiency of such enzymes leads to low tolerance to metal contamination while mutants over-expressing them are highly tolerant to metal contamination and may be used in phyto-remediation of heavy metals.
  • Immunogen: Synthetic peptide
  • Isotype: IgG2a
  • Research area: Plant Science; Cell Signaling & Signal Transduction

  • For Research Use Only

Target Details

  • Target: Gamma-Glutamylcysteine Synthetase
  • Target background: Together with glutathione synthetase and phytochelatin synthetase, gamma-glutamyl Cys sythetase (Î?-ECS) is an enzyme involved in, and required for, synthesizing phytochelatins (PC). Î?-ECS is involved in the biosynthesis of Glutathione. PC are multidentate ligands that are able to form chelates with thio-reactive, “soft” metal cations such as Cd2+, Hg2+, and at least one oxoanion (AsO33-). In certain plants, deficiency of such enzymes leads to low tolerance to metal contamination while mutants over-expressing them are highly tolerant to metal contamination and may be used in phyto-remediation of heavy metals.

Application Details

  • Application: ELISA ; IF ; WB

Handling

  • Format: Liquid
  • Storage buffer:
  • Storage conditions:
  • Shipping conditions: Shipping at 4°C

Documentation

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  • Available on request

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References

  • •  LeBlanc et al. 2011. Int J Phytoremediation. 13(7):657-73. PMID: 21972493.
  • •  Enhanced arsenic tolerance of transgenic eastern cottonwood plants expressing gamma-glutamylcysteine synthetase.
  • •  Li et al. 2005. Environ Toxicol Chem. 24(6):1376-86. PMID: 16117113.
  • •  Arsenic and mercury tolerance and cadmium sensitivity in Arabidopsis plants expressing bacterial gamma-glutamylcysteine synthetase.
  • •  Dhankher et al. 2002. Nat Biotechnol. 20(11):1140-5. PMID: 12368812.
  • •  Engineering tolerance and hyperaccumulation of arsenic in plants by combining arsenate reductase and gamma-glutamylcysteine synthetase expression.
  • •  Li et al. 2001. Plant Physiol. 127(3):711-9. PMID: 11706154.
  • •  Rapid isolation of monoclonal antibodies. Monitoring enzymes in the phytochelatin synthesis pathway.