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Contributor Information

  • Institute Netherlands Cancer Institute

Tool Details

  • Tool name: Anti-cErbB2/HER2 [3B5]
  • Alternate names: NEU
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human ; Mouse ; Rat
  • Host: Mouse
  • Molecular weight of the target: 185 kDa
  • Application: IHC ; IF ; IP ; WB
  • Strain: Balb/c
  • Description: HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients
  • Immunogen: Mouse immunized with a synthetic peptide TAENPEYLGLDVPV corresponding to amino acid residues
  • Isotype: IgG1
  • Research area: Cancer; Cell signaling and signal transduction
  • Myeloma used: Sp2/0-Ag14

  • For Research Use Only

Target Details

  • Target: cErbB2/HER-2
  • Target molecular weight: 185 kDa
  • Target background: HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients

Application Details

  • Application: IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -20°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

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  • •  van Leeuwen et al. 1990. Oncogene. 5(4):497-503. PMID: 1970152.
  • •  van de Vijver et al. 1988. N Engl J Med. 319(19):1239-45. PMID: 2903446.
  • •  Varley et al. 1987. Oncogene. 1(4):423-30. PMID: 3330785.
  • •  Di Fiore et al. 1987. Science. 237(4811):178-82. PMID: 2885917.
  • •  Slamon et al. 1987. Science. 235(4785):177-82. PMID: 3798106.
  • •  Yamamoto et al. 1986. Nature. 319(6050):230-4. PMID: 3003577.
  • •  Bargmann et al. 1986. Nature. 319(6050):226-30. PMID: 3945311.
  • •  Blick et al. 1984. Blood. 64(6):1234-9. PMID: 6208953.