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Contributor Information

  • Institute Netherlands Cancer Institute

Tool Details

  • Tool name: Anti-DGKa [M6]
  • Alternate names: DGKA; Diacylglycerol Kinase Alpha
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 77 kDa
  • Application: IP ; WB
  • Immunogen: Immunized with an Escherichia coli cell-expressed, affinity-purified glutathione S-transferase protein of a C-terminal portion (part of the Catalytic domain) of Rat DGKu.
  • Research area: Cell Signaling & Signal Transduction ; Immunology ; Metabolism

  • For Research Use Only

Target Details

  • Target: DGKa
  • Target molecular weight: 77 kDa
  • Target background: Diacylglycerol kinase alpha is an enzyme that belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signalling pathways. It also plays an important role in the resynthesise of phosphatidylinositol's and phosphorylating diacylglycerol to phosphatidic acid.

Application Details

  • Application: IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C
  • Mycoplasma free: Yes

Documentation

  • Available on request

References

  •   Cutrupi et al. 2000. EMBO J. 19(17):4614-22. PMID: 10970854.
  •   Schaap et al. 1993. Biochem J. 289 ( Pt 3):875-81. PMID: 7679574.