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Contributor Information

  • Institute Absolute Antibody; University of Oxford

Tool Details

  • Tool name: Anti-S100 [S1-61]
  • Clone: S1-61
  • Tool type: Antibodies
  • Tool sub-type: Primary Antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Description: S-100 protein is an acidic protein antigen present on certain cells and useful as a marker in anatomic pathology.The name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. The protein binds calcium and is structurally similar to calmodulin. The function of S-100 is unknown.S-100 is normally present in cells derived from the neural crest (Schwann cells, melanocytes, and glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, and dendritic cells. It may be present in some breast epithelial cells.
  • Immunogen: S-100 protein conjugated to methylated BSA
  • Isotype: IgG1
  • Research area: Other

  • For Research Use Only

Target Details

  • Target: S100
  • Target background: S-100 protein is an acidic protein antigen present on certain cells and useful as a marker in anatomic pathology.The name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. The protein binds calcium and is structurally similar to calmodulin. The function of S-100 is unknown.S-100 is normally present in cells derived from the neural crest (Schwann cells, melanocytes, and glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, and dendritic cells. It may be present in some breast epithelial cells.

Application Details

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  New sites of human S-100 immunoreactivity detected with monoclonal antibodies.
  • •  Production of monoclonal antibodies directed against antigenic determinants common to the alpha- and beta-chain of bovine brain S-100 protein.
  • •  Vanstapel et al. 1985. Lab Invest. 52(2):232-8. PMID: 2578587.
  • •  Vanstapel et al. 1986. Am J Clin Pathol. 85(2):160-8. PMID: 2418676.