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Contributor Information

  • Institute Absolute Antibody; Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: Anti-XRCC3 [XRCC3 10F1/6]
  • Clone: XRCC3 10F1/6
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Recombinant
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 37.8 kDa
  • Immunogen: His-tagged human XRCC3
  • Research area: DNA Damage and Repair ; Epigenetics & Nuclear Signalling

  • For Research Use Only

Target Details

  • Target: XRCC3
  • Target molecular weight: 37.8 kDa
  • Target background: X-Ray Repair Cross Complementing 3 (XRCC3) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC3 is also a component of the homologous recombination pathway.

Application Details

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

  • Available on request

References

  •   Complex formation by the human RAD51C and XRCC3 recombination repair proteins.
  •   Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.
  •   Identification and purification of two distinct complexes containing the five RAD51 paralogs.
  •   Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635.
  •   Masson et al. 2001. Proc Natl Acad Sci U S A. 98(15):8440-6. PMID: 11459987.
  •   Tebbs et al. 1995. Proc Natl Acad Sci U S A. 92(14):6354-8. PMID: 7603995.