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Contributor Information

  • Institute Versiti Blood Research Institute

Tool Details

  • Tool name: Anti-AP-1 (Glycoprotein Ib) [MBC-1]
  • Alternate names: GpIb
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Molecular weight of the target: 145
  • Application: ELISA
  • Description: GPIb is a platelet glycoprotein and a receptor for von Willebrand factor. Consists of alpha and beta subunits. Forms a multiprotein complex with GPIX and GPV. Binding of VWF to this complex initiates platelet adhesion to the sub-endothelium after vascular injury. Binding of AP-1 to GP1b alpha inhibits binding of VWF to GP1b alpha.
  • Immunogen: GPIba
  • Research area: Immunology
  • Myeloma used: P3X63Ag8.653

  • For Research Use Only

Target Details

  • Target: Glycoprotein 1B
  • Target molecular weight: 145
  • Target background: GPIb is a platelet glycoprotein and a receptor for von Willebrand factor. Consists of alpha and beta subunits. Forms a multiprotein complex with GPIX and GPV. Binding of VWF to this complex initiates platelet adhesion to the sub-endothelium after vascular injury. Binding of AP-1 to GP1b alpha inhibits binding of VWF to GP1b alpha.

Application Details

  • Application: ELISA

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1mg/ml
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15°C to -25°C
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Rosenberg et al. 2002. Blood. 100(5):1699-706. PMID: 12176890.
  • •  Sims et al. 1991. J Biol Chem. 266(12):7345-52. PMID: 1902217.
  • •  Okita et al. 1985. J Cell Biol. 100(1):317-21. PMID: 3155520.