ANTIBODIES
Contributor Information
- Name Andrew Hollenbach
- Institute Louisiana University Health Sciences Center New Orleans (LSU)
Tool Details
- Tool name: Anti-phospho Pax3 [Ser209]
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human ; Mouse
- Host: Rat
- Application: WB
- Description: Pax3 is a transcription factor important for myogenesis and when dysregulated can cause pediatric solid muscle tumor alveolar rhabdomyosarcoma (ARMS). ARMS is primarily characterized by the t(2;13)(p35;p14) chromosomal translocation, which results in the oncogenic fusion protein Pax3-FOXO1. Using these phospho-specific antibodies it was demonstrated that the pattern of Pax3 phosphorylation at serines 201, 205, and 209 changes throughout early myogenic differentiation and that this pattern is different for Pax3-FOXO1 in primary myoblasts and in several ARMS cell lines.
- Immunogen: synthetic peptide: NH2-DID(pS)EPDLPLKRC-CO2
- Research area: Myogenesis
- For Research Use Only
Target Details
- Target: Phosphorylated Ser209 of Pax3
- Target background: Pax3 is a transcription factor important for myogenesis and when dysregulated can cause pediatric solid muscle tumor alveolar rhabdomyosarcoma (ARMS). ARMS is primarily characterized by the t(2;13)(p35;p14) chromosomal translocation, which results in the oncogenic fusion protein Pax3-FOXO1. Using these phospho-specific antibodies it was demonstrated that the pattern of Pax3 phosphorylation at serines 201, 205, and 209 changes throughout early myogenic differentiation and that this pattern is different for Pax3-FOXO1 in primary myoblasts and in several ARMS cell lines.
Application Details
- Application: WB
Handling
- Format: Liquid
- Shipping conditions: Shipping at 4°C
Documentation
- Available on request
Related Tools
References
- • Loupe et al. 2015. Oncogenesis. 4:e145. PMID: 25821947.
- • Dietz et al. 2011. Int J Biochem Cell Biol. 43(6):936-45. PMID: 21440083.
.svg)
Unit size: 
.svg)
.svg)
