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Contributor Information

  • Institute University of Georgia

Tool Details

  • Tool name: Anti-Bordotella avium 41-kDa Surface Protein [14G8]
  • Tool type: Antibodies
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Bordotella avium
  • Host: Mouse
  • Molecular weight of the target: 41
  • Application: ELISA ; IF ; WB
  • Description: Bordotella avium, a Gram-negative, aerobic and motile bacterium, is the causative agent of turkey coryza, an economically-impacting disease that can also infect other birds. The bacterium has been isolated from individuals with cystic fibrosis, although the contribution of the organism to the disease is still unclear.B. avium shares several virulence factors with human pathogens. A 41 kDa surface protein of B. avium is strongly associated with the organism’s virulence and ability to attach to tracheal mucosa. Monoclonal antibodies designated 9F8, 1G12 and 14G8 immunoprecipitate the 41kDa protein and also inhibited HA of guinea pig erythrocytes by B. avium. These antibodies have the potential to be used in the development of therapeutic and/or diagnostic tools.
  • Immunogen: CsCl-purified protein from B. avium 002/S isolate
  • Research area: Bacteriology
  • Myeloma used: Sp2/0

  • For Research Use Only

Target Details

  • Target: Bordotella avium 41-kDa Surface Protein
  • Target molecular weight: 41
  • Target background: Bordotella avium, a Gram-negative, aerobic and motile bacterium, is the causative agent of turkey coryza, an economically-impacting disease that can also infect other birds. The bacterium has been isolated from individuals with cystic fibrosis, although the contribution of the organism to the disease is still unclear.B. avium shares several virulence factors with human pathogens. A 41 kDa surface protein of B. avium is strongly associated with the organism’s virulence and ability to attach to tracheal mucosa. Monoclonal antibodies designated 9F8, 1G12 and 14G8 immunoprecipitate the 41kDa protein and also inhibited HA of guinea pig erythrocytes by B. avium. These antibodies have the potential to be used in the development of therapeutic and/or diagnostic tools.

Application Details

  • Application: ELISA ; IF ; WB

Handling

  • Format: Liquid
  • Storage buffer:
  • Storage conditions:
  • Shipping conditions: Shipping at 4°C

Documentation

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  • Available on request

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References

  • •  Harrington et al. 2009. Emerg Infect Dis. 15(1):72-4. PMID: 19116056.
  • •  Moore et al. 1994. Avian Dis. 38(2):218-24. PMID: 7980267.
  • •  Moore et al. 1994. Avian Dis. 38(1):50-8. PMID: 8002900.
  • •  Domingo et al. 1992. Avian Dis. 36(3):707-13. PMID: 1358051.
  • •  Jackwood et al. 1991. Avian Dis. 35(3):496-504. PMID: 1953575.