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Contributor Information

  • Name Urpo Lamminmäki
  • Institute University of Turku

Tool Details

  • Tool name: Anti-GTP [2A4]
  • Tool type: Antibodies
  • Tool sub-type: Primary antibody
  • Class: Monoclonal
  • Conjugate: Unconjugated
  • Reactivity: Human
  • Application: ELISA ; FACS ; IF
  • Description: GTPases are central cellular signaling proteins, which cycle between a GDP-bound inactive and a GTP-bound active conformation in a controlled manner. Ras GTPases are frequently mutated in cancer and so far only few experimental inhibitors exist. The most common methods for monitoring GTP hydrolysis rely on luminescent GDP- or GTP-analogs. (From Kopra et al Anal. Chem. 2015, 87, 6, 3527–3534)
  • Research area: Cancer; Metabolism

  • For Research Use Only

Target Details

  • Target: GTP
  • Target background: GTPases are central cellular signaling proteins, which cycle between a GDP-bound inactive and a GTP-bound active conformation in a controlled manner. Ras GTPases are frequently mutated in cancer and so far only few experimental inhibitors exist. The most common methods for monitoring GTP hydrolysis rely on luminescent GDP- or GTP-analogs. (From Kopra et al Anal. Chem. 2015, 87, 6, 35273534)

Application Details

  • Application: ELISA ; FACS ; IF

Handling

  • Format: Liquid
  • Shipping conditions: Shipping at 4°C

Documentation

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References

  • •  Kopra et al. 2017. Anal Chem. 89(8):4508-4516. PMID: 28318223.
  • •  Kopra et al. 2015. Anal Chem. 87(6):3527-34. PMID: 25707436.