- Name Tony Marion
- Institute The University of Tennessee Health Science Center (UTHSC)
Tool name: Anti-DNA [m17-s130]
Tool type: Antibodies
Description: Monoclonal anti-DNA antibodies were generated from a spontaneous mouse model of Systemic Lupus Erythematosus (SLE) (NZB x NZW)F1 using standard methodologies for the generation of B-cell hybridomas. The mice spontaneously developed anti-DNA antibodies that contributed to SLE disease. The mice were neither immunized nor stimulated non-specifically. Hybridomas derived from these autoimmune mice provide the opportunity to analyse the structure, function, and biology of autoantibodies important to understanding their contribution to the pathogenesis of SLE. Table 1 provides a summary of the variable region structures and DNA specificity for the monoclonal anti-DNA autoantibodies generated.
Research area: Immunology
- For Research Use Only
- • Marion et al. 1997. Methods. 11(1):3-11. PMID: 8990083.
- • Tillman et al. 1992. J Exp Med. 176(3):761-79. PMID: 1512540.
- • Marion et al. 1982. J Immunol. 128(2):668-74. PMID: 7198664.