ANTIBODIES
Contributor Information
- Name Abdo Alnabulsi
- Institute Vertebrate Antibodies Limited
Tool Details
- Tool name: Anti-Irisin [VAB11 P2C12*C11]
- Tool type: Antibodies
- Class: Monoclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Mouse
- Molecular weight of the target: 12
- Application: ELISA ; IHC ; WB
- Strain: Balb/c
- Description: Irisin belongs to the class of adipomyokines since it acts both in adipose and muscle tissue (adipokine and myokine) and is a thermogenic protein that promotes energy expenditure by white adipose tissue (WAT) browning. Irisin is secreted from muscles in response to exercise and may mediate some beneficial effects of exercise in humans, such as weight loss and thermoregulation. Irisin is a cleavage protein of fibronectin type III domain 5 (FNDC5). FNDC5 converts to irisin after exercise. Irisin dissipates energy as heat and for this reason its discovery has generated a flurry of research aimed at understanding the mechanisms of energy metabolism. Irisin is expected to be a potential therapeutic agent for the treatment of obesity and its related conditions. This tool is significant as the peptide immunogen used to generate antibodies is conserved across all vertebrates.
- Immunogen: Ovalbumin-conjugated synthetic peptide. Peptide immunogen is conserved across all vertebrates.
- Isotype: IgG
- Research area: Cell biology; Immunology
- For Research Use Only
Target Details
- Target: Irisin
- Target molecular weight: 12
- Target background: Irisin belongs to the class of adipomyokines since it acts both in adipose and muscle tissue (adipokine and myokine) and is a thermogenic protein that promotes energy expenditure by white adipose tissue (WAT) browning. Irisin is secreted from muscles in response to exercise and may mediate some beneficial effects of exercise in humans, such as weight loss and thermoregulation. Irisin is a cleavage protein of fibronectin type III domain 5 (FNDC5). FNDC5 converts to irisin after exercise. Irisin dissipates energy as heat and for this reason its discovery has generated a flurry of research aimed at understanding the mechanisms of energy metabolism. Irisin is expected to be a potential therapeutic agent for the treatment of obesity and its related conditions. This tool is significant as the peptide immunogen used to generate antibodies is conserved across all vertebrates.
Application Details
- Application: ELISA ; IHC ; WB
Handling
- Format: Liquid
- Storage buffer:
- Storage conditions:
- Shipping conditions: Shipping at 4Ă°C
Documentation
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