ANTIBODIES
Contributor Information
- Name Tambet Teesalu
- Institute University of Tartu
Tool Details
- Tool name: Anti-FN-EDB
- Tool type: Antibodies
- Tool sub-type: Primary antibody
- Class: Polyclonal
- Conjugate: Unconjugated
- Reactivity: Human
- Host: Rabbit
- Application: ELISA ; IHC
- Description: Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are nearly absent in extracellular matrix of normal adult tissues but upregulated in malignant tissues. Both FN-EDB and TNC-C are developed as targets of antibody-based therapies. This series of antibodies has been validated in vitro against glioblastoma (GBM) and prostate carcinoma xenografts, and to non-malignant angiogenic neovessels induced by VEGF-overexpression. Please see our related anti-FN-EDB antibodies from University of Tartu.
- Research area: Extracellular Matrix; Cancer Microenvironment
- For Research Use Only
Target Details
- Target: extra domain B of fibronectin, EDB-FN
- Target background: Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are nearly absent in extracellular matrix of normal adult tissues but upregulated in malignant tissues. Both FN-EDB and TNC-C are developed as targets of antibody-based therapies. This series of antibodies has been validated in vitro against glioblastoma (GBM) and prostate carcinoma xenografts, and to non-malignant angiogenic neovessels induced by VEGF-overexpression. Please see our related anti-FN-EDB antibodies from University of Tartu.
Application Details
- Application: ELISA ; IHC
Handling
- Format: Liquid
- Shipping conditions: Shipping at 4°C
Documentation
- Available on request
Related Tools
References
- • Lingasamy et al. 2019. Biomaterials. 219:119373. PMID: 31374479.
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