1-7HB2 Cell Line
- Name Joyce Taylor-Papadimitriou
- Institute Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool name: 1-7HB2 Cell Line
Tool type: Cell Lines
Tool sub-type: Continuous
Parental cell line: MTSV1-7
Description: The 1-7HB2 cell line is a clonal derivative of the human mammary luminal epithelial cell line MTSV1-7 identified by screening for branching morphology. It is a potent tool for in vitro study of branching morphogenesis of human mammary epithelial cells and the role of integrins in mammary morphogenesis. MTSV1-7 is a clonal non-tumourigenic cell line developed by immortalizing luminal epithelial cells cultured from milk using the SV40 T antigen. The cell line forms branching structures in the presence of fibroblast cultures or fibroblast-conditioned medium and forms spheroids in collagen type I gels.
Research area: Cell Structure and Motility
- For Research Use Only
- • Bartek et al. 1991. Proc Natl Acad Sci U S A. 88(9):3520-4. PMID: 1708884.
- • Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirus.