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Contributor Information

  • Name Thomas Lindahl
  • Institute Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details

  • Tool name: MEF UNG KO Cell Line
  • Tool type: Cell Lines
  • Organism: Mouse
  • Tissue: Embryo
  • Cancer type: B cell lymphoma
  • Disease: Cancer
  • Description: The MEF UNG KO Cell Line is a tool for in vivo study of the function of UNG and the effects of DNA mismatch during DNA synthesis. UNG encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway.
  • Research area: DNA Damage and Repair

  • For Research Use Only

Target Details

Application Details

Handling

  • Format: Frozen
  • Growth medium: DMEM:F12 (1:1) + 10% FCS.
  • Shipping conditions: Dry ice

Documentation

  • Available on request

References

  •   Nilsen et al. 2003. Oncogene. 22(35):5381-6. PMID: 12934097.
  •   Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas.